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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

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~24+ hours (estimated from animal models, duration of effect up to 28 days) ~23-30 days (depot formulation) ~12.7 days (IV, rat) ~9 days (220 hours) ~5 hours plasma (functional tissue activity persists 7-10 days) ~8 days (testosterone cypionate IM) ~7 days (semaglutide component ~158h