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Psychological factors influence real-world outcomes even when pharmacological mechanisms are superior

Current evidence suggests that these effects are more likely attributable to rapid improvements in glycemic control rather than a direct pharmacological action of GLP-1 RAs

There is large inter-person variability in response to GLP1 medications both in terms of weight loss and side effects, with the two potentially being related (that is, people who experience more nausea may lose more weight 30 )

The Dutch Eating Behaviour Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior