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Despite the absence of a statistically significant doseresponse relationship observed in this analysis, clinical decision-making should consider that absorption efficiencyrather than absolute dosagemay be the limiting factor

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To resolve the uncertainty, an adequately powered publicly-funded randomized, placebo-controlled trial run over several seasons should be undertaken. A 2010 Cochrane Database review of 50 studies including over 70,000 people, found that influenza vaccines have a modest effect in reducing influenza symptoms and working days lost