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Identification of caspase-8 as a cell fate-regulating enzyme in mature erythrocytes might have far-reaching implications for RBC biology, since the ability to regulate and select cell death modalities questions a conceptual view on erythrocytes as entities existing in a state between life and death

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Knockdown of AdipoR1 decreased the protective effects of schisandrin A in a DN mouse model, while the AdipoR1 agonist gramine exerts the opposite effect, indicating that AdipoR1 may be a potential target of SA in a DN model [246]