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It is established cardiac pharmacology, documented in the NEJM paper: "Glucagon and GLP-1 can exert positive chronotropic and inotropic effects on the heart." GLP-1 also contributes: GLP-1 receptor activation by itself produces a modest chronotropic effect this is why semaglutide and tirzepatide raise heart rate by 14 bpm

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Particularly since 2009, the introduction of dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) has significantly transformed diabetes care in Japan (Fig