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For patients focused on stronger weight loss, standard-dose semaglutide or tirzepatide may be the better starting point

A comprehensive database search was conducted in PubMed, MEDLINE, Scopus, Embase, and Google Scholar covering the period from inception (1996, 1966, 2004, 1947 and 2004, respectively) to September 2025

This expansion also highlights the limitations of the body mass index (BMI) in defining obesity, as many individuals with normal or mildly elevated BMIs may perceive themselves as needing intervention

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