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paracasei evoked vagal firing in colonic tissue with an intact epithelium, which may be mediated through activation of GLP-1Rs on L-cells leading to basolateral secretion of GLP-1 and subsequent activation of vagal afferents (Bohrquez et al., 2015)

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In a meta-analysis with patients with T1D, weight loss with liraglutide 1.8 mg was estimated at ~5 kg compared to placebo (62), and there was a dose-response effect