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Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment

37 DRUG INTERACTIONS Previous trials investigating potential drug interactions with SC semaglutide have yielded few notable interactions, most likely due to the nonspecific mechanisms of metabolism seen with semaglutide

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