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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

For more information on inclusion and exclusion criteria in the individual trials, see the trial publications [13,14,15, 19, 20]

doi: 10.1172/JCI990 20 LarsenPJFledeliusCKnudsenLBTang-ChristensenM

This can lead to instability, awkward movements, and flare-ups of pain