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In addition, as caspases are oxidant stress sensitive exhibiting dual regulation by ROS, it is conceivable that overt oxidative stress and ROS generation may block caspase activation despite release of apoptosis factors from mitochondria

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However, the beneficial effects of modafinil have been primarily observed in mice, and further clinical studies are necessary to validate its efficacy and safety in humans ( Immunotherapy strategies, such as MHC/neuroantigen peptide constructs, have emerged as experimental approaches for treating METH-induced learning and memory deficits

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