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It does not necessarily lead to a significantly lighter skin tone in everyone

But we rarely have such evidence, so instead, we have to rely on statistical techniques that allow you to make indirect comparisons. Its also difficult to say definitively how DORA drugs compare with older treatments for insomnia, but Buysse says that drug registration trials suggest that DORA drugs have fewer adverse cognitive or hangover effects compared with benzodiazepines and Z-drugs, as well as less potential for dependence and misuse