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Finally, we explored the therapeutic effect of FOXO4-DRI in naturally aged mice, and demonstrated that FOXO4-DRI alleviates age-related testosterone secretion insufficiency and improves the testicular microenvironment

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Moreover, the administration of NAC was observed to enhance both GSH levels in rats eyes and the intracellular GSH pool in RPE cells, predisposing RPE cells to ferroptosis resistance in AMD (134)