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HSP is a highly conserved family of stress-inducible proteins, essential for cellular homeostasis, protecting against a variety of stress stimulus [83, 84], injury, and death and modulating the early inflammatory response to muscle injury [30, 31]

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Rather than merely debating compounding categories, regulatory bodies must recognize that without robust oversight and a strict mandate for high-quality clinical evidence, the widespread adoption of these signaling molecules will continue to outpace our clinical understanding of their long-term safety, effectively turning an entire generation of patients into an unregulated experiment

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