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Considering that Akt1 is a canonical kinase and NIK has some phosphorylation modification sites, we performed CO-IP and found no direct interaction between NIK and p-Akt1 (Fig S4D)

Starting with a low dose and gradually increasing it helps minimize these side effects

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Oral: Shorter systemic half-life, longer local GI effect SubQ/IM Injection: Longer systemic presence, especially with IM use 3