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GLP-1 agonists produce greater sustained weight loss, typically 1525% body weight reduction over 68 weeks in trials, compared to phentermine's 510% over 12 weeks

Pregnancy and breastfeeding : Pregnant or breastfeeding individuals should avoid semaglutide entirely

This multi-receptor targeting approach potentially offers a more comprehensive metabolic effect by enhancing insulin sensitivity, reducing hunger, and increasing energy expenditure through glucagon activity

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