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Ultimately, it destroys the single most important thing in research: reproducibility

doi: 10.1038/209794a0 64 GBD 2016 Multiple Sclerosis Collaborators (2019)

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Quick Takeaways Retatrutide (GLP-1/GIP/glucagon receptor agonist) shows up to 2428.7% body weight loss in Phase 2 & 3 trials, outperforming both Tirzepatide and Semaglutide but not yet FDA-approved Tirzepatide (GLP-1/GIP receptor agonist) delivers 2022.5% weight loss and is FDA-approved, beating Semaglutide by ~47% in head-to-head trials Semaglutide (GLP-1 receptor agonist) produces 1415% weight loss and remains the most widely prescribed, but is mechanistically inferior to dual and triple agonists All three share gastrointestinal side effects