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Review of the dermorphin family: selective mu-opioid agonists, potent analgesics in rodents and primates, some able to cross the blood-brain barrier after peripheral dosing, with reports of less tolerance/dependence than morphine in animal studies

Parkinsonism is often discussed in terms of dopamine deficiency, alpha-synuclein pathology, or selective neuronal vulnerability, and each of these perspectives remains important

The research story is more cautious than the social-media story