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So, while DPP-IVs may offer a better gastrointestinal (GI) adverse event profile than GLP-1RAs, they are generally less effective at reducing HbA 1C and have a lower potential for weight loss

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The FDA also approved Wegovy for weight loss in people who are obese (have a body mass index [BMI] of 30 or greater) or overweight (have a BMI of 27 or greater) and have at least one weight-related health condition

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Gradual dose titration remains the most effective preventive approach

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