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Functional Assessments Range of motion testing measured with a goniometer at consistent intervals (weekly) Pain scales standardized VAS (visual analog scale) scores, recorded at the same time of day Strength testing grip strength, manual muscle testing, or machine-based measurement Gait analysis for lower extremity injuries, tracking stride length and symmetry GI symptom diaries for gut-related applications, daily tracking of symptoms (bloating, pain, stool quality) Biomarkers CRP (C-reactive protein) systemic inflammation marker

10.1186/1741-7015-11-129 366 PerrinM.VandeleurC

Neurobiol Dis 37:519533 Lu M, Yang J, Geng F, Ding J, Hu G (2014) Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis