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Although Bcr-Abl inhibitors such as imatinib, nilotinib, and dasatinib are effective in CML therapy 7,8,9 , the acquisition of the T315I mutation of BCR-ABL in patients causes the resistance to most tyrosine kinase inhibitors (TKI), leading to poor outcomes

In a recent study, pharmacological inhibition of NLRP3 inflammasome by MCC950 improved pathological damage and reduced inflammatory response in experimental pancreatitis ( 5 TCM used to relieve AP by targeting NLRP3 In Chinese medicine (CM), AP is classified under abdominal pain ( Futong ), spleen-heart pain ( Pi Xintong ), and pancreatic inflammation ( Yi Dan ) ( Gan Yu ), trauma, and invasion of exogenous pathogens ( Liu Yin ) (Wu, 2002), all of which may exacerbate the progression of AP

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