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A dosage of 250 g is still very high especially considering that the average content in B12-rich foods is 3-5 g per 100g

doi:10.1136/jnnp.2007.133025

The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular, funding from the Operational Infrastructure Support Grant

Stability degrades significantly if exposed to room temperature for more than 2 hours cumulatively or if frozen after reconstitution freezing causes ice crystal formation that disrupts protein structure