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The parameters of GO analysis were set as follows: min overlap = 3, p-value cutoff = 0.05, min enrichment = 1.5

Classic examples include native GLP-1, which has a plasma half-life of approximately 2 minutes and required continuous infusion in early studiesan impractical route for chronic therapyyet was subsequently transformed into a once-weekly therapeutic through lipidation and albumin-binding strategies ( Third, pleiotropic signaling that aligns with physiological function rather than nonspecific toxicity favors re-evaluation

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& Gouon-Evans, V