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Sermorelin mimics growth hormone-releasing hormone, while ipamorelin stimulates growth hormone release through ghrelin receptor activity

Several mechanisms could theoretically explain respiratory symptoms in patients taking Mounjaro , though none are definitively established: Gastro-oesophageal reflux disease (GORD) : The delayed gastric emptying caused by tirzepatide (noted in the SmPC) may theoretically exacerbate reflux symptoms in susceptible individuals, potentially leading to chronic cough through aspiration or irritation of the airways [1] Allergic or hypersensitivity reactions : Though uncommon, any medication can potentially trigger allergic responses, which may include respiratory manifestations Coincidental respiratory infections : Patients may develop upper respiratory tract infections unrelated to their diabetes medication It is crucial to consider alternative explanations for cough in patients taking Mounjaro

The investigators reported that rapid weight loss with such medications might also lead to substantial muscle loss

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