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A mechanistic search for a common denominator focuses on the generalized central neuronal hyperexcitability, genetically driven by mutations in genes coding for ion-channels and mutations in mtDNA

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Moderate-intensity exercise such as brisk walking, swimming, or cycling can reduce stress and improve overall metabolic health

This repression was hypothesized to be important for stem cell maintenance since RNAi-mediated knockdown of mpk-1 increased the number of mitotic germ cells, while promoting MPK-1 activity by a Ras gain-of-function mutation let-60(n1046) decreased the number of mitotic germ cells (Lee et al., 2006)