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In general, nutrients modulate DNA methylation by acting as methyl donors (methionine, choline, and folate), providing co-factors essential for methyltransferases activity (vitamins B2, B6, and B12) and modulating the activity of enzymes in the methylation process (polyphenol) (161)

For instance, emerging research suggests that elevated body fat percentage in conjunction with low lean muscle masscalled sarcopenic obesityis associated with poor kidney-related health outcomes

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After finishing the experiment, the mice skull were wiped with lidocaine (0.25%, AstraZeneca), and the mice scalp were glued with Tissue Adhesive (3 M Vetbond)