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However, GLP-1 analogs do present some drawbacks

Because these enzymes are responsible for metabolizing a vast majority of pharmaceutical drugs, taking berberine can significantly elevate the blood concentrations of co-administered medications, potentially leading to dangerous toxicity

Interestingly, certain muscle groups, notably the rectus abdominis, psoas major, and paraspinal muscles , appeared to display more pronounced changes, which were typified by either an augmentation in muscle density and size or a diminution in fat content

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