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In a different reaction, 1 O 2 is produced by oxidation of H 2 O 2 and HOCl, catalysed by myeloperoxidase (MPO) enzyme while CYP 2E1 from ER and cytochrome c from mitochondria contribute to the formation of 1 O 2 atoms

Comparators were control groups receiving either standard care or placebo, which allows for robust comparison of the therapeutic efficacy of SGLT2Is in reducing cardiovascular events

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