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Clinical guidelines typically focus on individuals within overweight or obesity ranges

TMAO is the compound responsible for the odor at high doses, and its also at the center of debates about heart health.61 62 Choline and TMAO Elevated blood TMAO has been linked to higher cardiovascular risk in observational studies, but the story is complicated.40Fish is one of the richest sources of TMAO, yet it consistently protects against heart disease.63 Individual microbiomes, kidney function, and the type of choline all affect how much TMAO you make.6 27 64 65 66 67 Free choline salts (like bitartrate, citrate, or chloride) tend to raise TMAO the most

Additionally, women with PCOS demonstrated specific alterations in their gut microbiome, including an increased abundance of Actinobacteria and Candidatus

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