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Leydig cell desensitization One theoretical concern with HCG involves potential desensitization of Leydig cells to LH stimulation

Its been tested in multiple double-blind RCTs for visceral fat reduction and is FDA-approved to reduce visceral fat in HIV-associated lipodystrophy

4 Mechanism of PYY improving insulin resistance PYY improves insulin resistance not through a single mechanism, but via a complex network of regulatory pathways involving the central nervous system and multiple peripheral metabolic organs