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SURPASS-CVOT compared once-weekly tirzepatide with dulaglutide in adults with type 2 diabetes and high cardiovascular risk, showing a 9% relative risk reduction in MACE (HR 0.92, 95% CI 0.83 to 1.01)

"Our findings could help inform patients and providers regarding some of the key factors that are associated with the probability of achieving sustained weight loss of a magnitude large enough to provide clinically significant health benefits." More From Newsweek Vault: What Is a Health Savings Account

OBES SURG 32 , 32803288 (2022)

For many patients on the weight-loss medications known as GLP-1s (glucagon-like peptide-1s), such as semaglutide, tirzepatide and liraglutide, the question of when or whether to stop is inevitable