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As an adjunct in the treatment of cardiac arrest and profound hypotension Contraindications: (see also - Drug Interactions) Norepinephrine should not be given to patients who are hypotensive from blood volume deficits except as an emergency measure to maintain coronary and cerebral artery perfusion until blood volume replacement therapy can be completed

And it explains why some patients who respond poorly to liraglutide see better results when switching to semaglutide, despite both drugs targeting the exact same receptor

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These treatments arent a onesizefitsall solution, but certain people tend to see the most significant benefits