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Supplementary material The Supplementary Material for this article can be found online at: References 1 PanwarBSchmiedelBJLiangSWhiteBRodriguezEKalunianKet al

Cagrilintide also has one of the lowest GI odds ratios among the incretin and amylin compound class in a 2025 Bayesian network meta-analysis of multi-target obesity therapies the relevance for the stack is that adding cagrilintide to retatrutide may not compound GI burden as severely as adding a second GLP-1 agonist would

Introduces residual gastric content that slows emptying and dilutes peptide concentration

In contrast, superficial peritoneal endometriosis was a poor predictor of postoperative pain relief in our study and was only included in one model