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Muthukumaran et al

A handful of people notice a difference almost right away, while for others it takes a bit longer to kick in

Although ACSS2 was initially believed to function as a cytoplasmic enzyme responsible for butyrate activation [51], recent evidence has shown that it lacks the catalytic capacity to generate butyryl-CoA or crotonyl-CoA directly from butyrate or crotonate in vivo [52]

Also, the lack of a comprehensive analysis of muscle mass across multiple muscle groups and tissues may have limited our ability to fully assess the impact of GLP-1 analogs on muscle health