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This work has culminated in the synthesis of a small molecule AT 4 receptor agonist capable of penetrating the blood-brain barrier and facilitating cognitive processing presumably by increasing synaptogenesis (133)

For individuals who meet the criteria for GLP-1 medications for weight loss, drugs such as Wegovy (Semaglutide) and Zebound (Tirzepatide) are FDA-approved treatment options

Moiz and colleagues found that retatrutide 12 mg weekly (Eli Lilly) showed the greatest effect on obesity among all agents in the review, producing weight loss of up to 22.1% (95% CI, 19.3%-24.9%) after 48 weeks of treatment