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IL-5 is mainly produced by T helper (Th2) and mast cells and stimulates B cell growth and activation, increasing antibody production [76]
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Exposure of rat Sertoli cells to RA led to activation of ROS generation, lipid peroxidation and, ultimately, a loss of cell viability.99 There is also some evidence to suggest that retinol might stimulate ROS generation in rat Sertoli cells99,100 and that this effect is accompanied by an upregulation of testicular antioxidant enzymes including SOD, GPx and catalase.101 There may be nothing particularly specific about this effect since retinoids have been shown to stimulate ROS generation in a variety of other cellular systems.102 Nevertheless, the free radical generation triggered by retinoids in the testes may explain the testicular degeneration induced by hypervitaminosis A in the rat103 and the association between excess beta carotene intake and infertility in human males.104 Impact of xenobiotics
Journal of the European Ceramic Society 36, 15391548, (2016)
