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9,10 Additionally, GLP-1 RAs suppress glucagon secretion from the -cells in the pancreas, leading to decreased blood glucose levels

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doi:10.1021/ja01581a033

The activated AKT will further activate the downstream regulatory pathway (the downstream target is mTOR), and the conversion process can be reversed by PTEN (a negative regulatory factor of PI3K) through dephosphorylation of PIP3 (229)