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This clinical study demonstrates that NAD+ declines with age in humans, highlighting age-associated shifts in redox balance and NAD+ metabolism that may contribute to aging and disease

Nevertheless, in some studies on TTFD, percent weight gain was lower in the TTFD group (254)

However, as SCD is increasingly recognized as a precursor to MCI and dementia, future research should focus on whether early VR-based cognitive training can effectively delay or mitigate cognitive decline in at-risk populations