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It governs a wide array of cellular processes, from antioxidant reactions to redox equilibrium, with a particular emphasis on lipid peroxidation and free iron accumulation processes [32]
GLP-1R knockout mice (GLP-1R KO, Shanghai Model Organisms, based on C57BL/6N) were generated using CRISPR/Cas9 technology, which causes Glp1r gene protein reading frame shift and loss of function by using non-homologous recombination repair to introduce mutations
It has been proposed that PD iron overload can act as a driver of oxidative stress and iron-mediated cell death, i.e
However, they have also offered new insights into the power of our own gut hormones
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