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You may experience mild swelling, redness, or tenderness in the treated area, but these effects typically subside within a few hours to a day

J Natl Cancer Inst 110(8):888-894, 2018

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The ARE activation can initiate the transcription of downstream antioxidant protective genes and phase II detoxification enzyme genes, which translates into HO-1, superoxide dismutase (SOD), NQO1, catalase, glutathione peroxidase, glutamate-cysteine ligase, glutathione-S-transferase and epoxide hydrolase, etc