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The litigation strategy for Paragraph IV challengers targeting CIP-derived patents now includes a standard step: identify all claims relying on new matter, confirm the parents publication date, calculate whether the one-year bar applies, and then analyze the parent for anticipation or obviousness arguments against the CIPs later claims

By addressing complementary mechanisms, the initial combination of vildagliptin and pioglitazone appears to be an effective means of achieving good glycemic control while attenuating drug-related adverse effects

A sleep study can determine if sleep apnea is contributing to poor sleep quality and whether temporary CPAP therapy is appropriate during the weight loss period

Some researchers have found that miR-382-5p expression is down-regulated and SLC7A11 expression is up-regulated in ovarian cancer tissues, and lidocaine targets the miR-382-5p/SLC7A11 axis (which up-regulates miR-382-5p expression and down-regulates SLC7A11 expression) to promote ferroptosis in ovarian cancer cells and exert anti-tumor activity (97)