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Visible collagen-driven changes emerge from week 6 to 8 and compound over 4 to 6 months of consistent bi-weekly use

DAlessandro A et al (2024a) Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease

Xi M, Hallemeier CL, Merrell KW, Liao Z, Murphy MAB, Ho L, Hofstetter WL , Mehran R, Lee JH, Bhutani MS, Weston B, Maru DM, Komaki R, Ajani JA, Lin SH

MS2quadrupole isolation at an isolation width of m / z 1.6, HCD fragmentation (NCE 30) with fragment ions scanning in the Orbitrap from m / z 110, 5 10 4 AGC target, 100 ms maximum injection time