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More importantly, when detailed cellular analyses were performed with electron microscopy (EM), exact same cellular problems were detected both in the UMNs of ALS patients with TDP-43 pathology and the CSMN of this mouse model of TDP-43 pathology 16
M1 TAMs display antitumorigenic characteristics, secreting cytokines like IL-12 to directly eliminate tumor cells and recruiting cytotoxic T cells for indirect antitumor effects (Li et al., 2021)
They also support wound healing and protect against oxidative damage
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