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The rates of prevention for preeclampsia, pregnancy-induced hypertension, and GDM were 92.7%, 92.8%, and 99.2%, respectively, compared with any other treatment or placebo ( 3.2.3 Impact of metformin on pregnant patients with polycystic ovary syndrome and preeclampsia Research has shown that metformin can inhibit the placental secretion of soluble fms-like tyrosine kinase 1 and promote arterial dilation, which suggests metformin may be a potential preventive and therapeutic agent for preeclampsia