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It is worth noting that only a few preclinical studies have been conducted with a dose range similar to that used in human clinical settings, and most of them used doses far above the tolerated human dose

In contrast, the FDA has not progressed to an investigative stage but continues to monitor situations closely

High levels of QA also increase the production of pro-inflammatory cytokines and chemokines, such as IL-8, monocyte chemoattractant protein-1 and RANTES, as well as chemokine receptor expression, in human fetal astrocytes [119]

If patients receive GLP1 medications outside their primary health system (for example, from telehealth) or change providers during the treatment, the EHR data collected in our study may not capture the full course of treatment, and this may explain our observation of generally shorter treatment durations, and hence less weight loss, recorded in EHRs