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Of particular importance, NRF2 activation in humans under some conditions can have disastrous consequences, as evidenced by the failed BEACON clinical trial of bardoxolone in human patients with type 2 diabetes and stage 4 chronic kidney disease [8]

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There is a theoretical --- though as yet unproven in humans --- risk that long-term or high-dose use could stimulate growth in existing malignant or pre-malignant cells