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Those companies, insurers say, have charged exorbitant amounts for the weight loss medicines, and the costs to insurers were unsustainable

Retatrutide is a 39-amino-acid synthetic peptide that engages three metabolic receptors simultaneously: the GLP-1 receptor, the GIP receptor, and the glucagon receptor

The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane