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GLP-1 has been tested as a regulator of anxiety behavior and both GLP-1 and exendin-4 (administered ip , into the lateral ventricle or intra-dorsal raphe) induced anxiety-like behavior, which was measured in the black and white box, elevated plus maze and open field tests in Spraque-Dawley rats [86]

2 Dopaminergic neurotransmission in PD pathogenesis The dopaminergic neurotransmission in PD pathogenesis involves the loss and apoptosis of dopaminergic neurons in the brain, as well as a reduction in dopamine levels, leading to an absolute deficiency of dopamine (15)