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4 Gharagozloo M, Smith MD, Sotirchos ES, et al

Recent studies revealed that Wilms tumor gene on the X chromosome (WTX) and PALB2, a major BRCA2 binding partner known as FANCN, have been shown to interact with the DC domain of KEAP1, inhibit the ubiquitination of Nrf2 and promote NRF2-dependent transcription ( WTX and PALB2 are both considered as tumor suppressor genes since their mutations are often found in kidney tumor (Wilms tumor) and breast and pancreatic cancers, respectively

Izquierdo-Condoy, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

TB500 is a synthetic version of thymosin beta-4, which is believed to play a role in the repair and regeneration of damaged cells and tissue