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Pyridoxine (B6) can reduce the effect of levodopa when levodopa is given without a peripheral decarboxylase inhibitor

[1] Other rare side effects noted (mostly in older literature or high-dose use) include: polycythemia vera and peripheral vascular thrombosis in patients receiving repeated injections (though these associations are not well understood, they were listed in prior product literature as possible adverse events)

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You typically get these vitamins from a nutritious diet