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Triterpenoid compounds such as 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivatives (CDDO-methyl ester and CDDO-imidazolide) allosterically inhibit LONP1 ATPase activity

When the cellular environment is well-supported, antioxidant systems work more efficiently, energy production is more consistent, and the body recovers from physical demands without falling significantly behind

109 Overall, there is a close association between TMAO and renal function, CKD, and cardiovascular outcomes in patients with CKD